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Giles et al., 1992 - Google Patents

Increased specificity for antisense oligodeoxynucleotide targeting of RNA cleavage by RNase H using chimeric methylphosphonodiester/phosphodiester structures

Giles et al., 1992

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Document ID
8654030663877603364
Author
Giles R
Tidd D
Publication year
Publication venue
Nucleic acids research

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Snippet

One of the inherent problems in the use of antisense oligodeoxynucleotides to ablate gene expression in cell cultures is that the stringency of hybridization in vivo is not subject to control and may be sub-optimal. Consequently, phosphodiester or phosphorothioate …
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