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Jahns, 2014 - Google Patents

Stereochemical and pharmacological properties of phosphorothioate siRNAs

Jahns, 2014

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Document ID
8631737309882086351
Author
Jahns H
Publication year

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Oligonucleotides are used as drugs, targeting cellular RNAs. To improve their pharmacokinetic properties, medicinal chemists exchanged their phosphodiester linkages for phosphorothioate (PS) groups. This PS-group is chiral at phosphorus (Rp/Sp centers) …
Continue reading at www.research-collection.ethz.ch (PDF) (other versions)

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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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