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Suh et al., 2003 - Google Patents

Hypoglycemic neuronal death and cognitive impairment are prevented by poly (ADP-ribose) polymerase inhibitors administered after hypoglycemia

Suh et al., 2003

View PDF @Free from Publisher
Document ID
858613223422423138
Author
Suh S
Aoyama K
Chen Y
Garnier P
Matsumori Y
Gum E
Liu J
Swanson R
Publication year
Publication venue
Journal of Neuroscience

External Links

Snippet

Severe hypoglycemia causes neuronal death and cognitive impairment. Evidence suggests that hypoglycemic neuronal death involves excitotoxicity and DNA damage. Poly (ADP- ribose) polymerase-1 (PARP-1) normally functions in DNA repair, but promotes cell death …
Continue reading at www.jneurosci.org (PDF) (other versions)

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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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