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An et al., 2021 - Google Patents

Adjuvant dendritic mesoporous silica nanoparticles as sustained delivery system for peptide-based vaccine

An et al., 2021

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Document ID
8425786110272360972
Author
An W
et al.
Publication year

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Peptide-based vaccines have raised as an attractive alternative strategy to overcome many of the limitations of conventional vaccines. Some drawbacks for an optimal immune response in vivo are, a poor immunogenicity, multivalency, a requirement of adjuvants and a …
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    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
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