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Spampanato et al., 2020 - Google Patents

Delayed adjunctive treatment of organophosphate-induced status epilepticus in rats with phenobarbital, memantine, or dexmedetomidine

Spampanato et al., 2020

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Document ID
8364367795735615101
Author
Spampanato J
Bealer S
Smolik M
Dudek F
Publication year
Publication venue
The Journal of Pharmacology and Experimental Therapeutics

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Organophosphate (OP) exposure induces status epilepticus (SE), a medical emergency with high morbidity and mortality. Current standard medical countermeasures lose efficacy with time so that treatment delays, in the range of tens of minutes, result in increasingly poor …
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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