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Chytil et al., 2006 - Google Patents

Properties of HPMA copolymer–doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification

Chytil et al., 2006

Document ID
828235850155928696
Author
Chytil P
Etrych T
Koňák
Šírová M
Mrkvan T
Říhová B
Ulbrich K
Publication year
Publication venue
Journal of controlled release

External Links

Snippet

Various conjugates of anticancer drug doxorubicin (DOX) covalently attached via hydrolytically degradable hydrazone bond to water-soluble N-(2-hydroxypropyl) methacrylamide (HPMA) copolymer drug carriers were synthesized. Three types of …
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    • A61K47/48169—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying agent being an organic macromolecular compound, i.e. an oligomeric, polymeric, dendrimeric molecule
    • A61K47/48176—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying agent being an organic macromolecular compound, i.e. an oligomeric, polymeric, dendrimeric molecule the organic macromolecular compound has been obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly(meth)acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol
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