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Muralidharan et al., 2022 - Google Patents

Long-term male-specific chronic pain via telomere-and p53‑mediated spinal cord cellular senescence

Muralidharan et al., 2022

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Document ID
8193844564487826234
Author
Muralidharan A
Sotocinal S
Yousefpour N
Akkurt N
Lima L
Tansley S
Parisien M
Wang C
Austin J
Ham B
Dutra G
Rousseau P
Maldonado-Bouchard S
Clark T
Rosen S
Majeed M
Silva O
Nejade R
Li X
Pimentel S
Nielsen C
Neely G
Autexier C
Diatchenko L
Ribeiro-da-Silva A
Mogil J
et al.
Publication year
Publication venue
The Journal of Clinical Investigation

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Snippet

Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular senescence in the spinal cord …
Continue reading at www.jci.org (HTML) (other versions)

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for mutation or polymorphism detection
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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