[go: up one dir, main page]

Valentijn et al., 1997 - Google Patents

Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein receptor

Valentijn et al., 1997

Document ID
7908249824641826410
Author
Valentijn A
van der Marel G
Sliedregt L
van Berkel T
Biessen E
van Boom J
Publication year
Publication venue
Tetrahedron

External Links

Snippet

Structurally well defined di-and tri-antennary lysine-based galactose-and N- acetylgalactosamine-containing ligands for the hepatic asialoglycoprotein receptor (ASGP- R) could be assembled on a solid support, using a combined Fmoc/Alloc protecting group …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C-Si linkages

Similar Documents

Publication Publication Date Title
Valentijn et al. Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein receptor
Biessen et al. Synthesis of cluster galactosides with high affinity for the hepatic asialoglycoprotein receptor
Rensen et al. Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor
US6383812B1 (en) Anti liver disease drug R-YEEE and method of synthesizing branched galactose-terminal glycoproteins
Hamzavi et al. Modulation of the pharmacokinetic properties of PNA: preparation of galactosyl, mannosyl, fucosyl, N-acetylgalactosaminyl, and N-acetylglucosaminyl derivatives of aminoethylglycine peptide nucleic acid monomers and their incorporation into PNA oligomers
Kovács et al. An easy access to anomeric glycosyl amides and imines (Schiff bases) via transformation of glycopyranosyl trimethylphosphinimides
US5608015A (en) Processes for producing cyclodextrin derivatives and polymers containing immobilized cyclodextrin therein
CN114716490B (en) GalNAc cluster phosphoramidites and targeted therapeutic nucleosides
JPS6399091A (en) O-alpha-glycoside and its production
SI9620099A (en) Diglycosylated 1,2-diols as mimetics of sialyl-lewis x and sialyl-lewis a
AU2017444369A1 (en) Modified oligonucleotides and compound that can be used for synthesizing same
Katajisto et al. An orthogonally protected α, α-bis (aminomethyl)-β-alanine building block for the construction of glycoconjugates on a solid support
Gan et al. Regiospecific syntheses of N-acetyllactosamine derivatives and application toward a highly practical synthesis of Lewis X trisaccharide
CN111233949A (en) A kind of ganglioside GM3 and/or its analog, synthetic method and application
FI87573B (en) FOER REFRIGERATION FOR EXAMINATION OF GANGLIOSIDLIKA FOERENINGAR
Cho et al. Chemoenzymatic total synthesis of the neuritogenic echinoderm ganglioside LLG‐5 and related analogues
Biessenb et al. Solid-phase Synthesis of Lysine-based Cluster Galactosides with High Affinity for the Asialoglycoprotein Receptor
Lubineau et al. First synthesis of the 3′-sulfated Lewisa pentasaccharide, the most potent human E-selectin ligand so far
Zheng et al. Synthesis of N-modified ganglioside GM3 derivatives
CN105581978A (en) Glucosamine derivative cation liposome nanoparticle preparation method
Berthod et al. Synthesis and mass spectrometry analysis of oligonucleotides bearing 5-formyl-2′-deoxyurldlne in their structure
Villard et al. Asymmetric Synthesis of Water‐Soluble Analogues of Galactosylceramide, an HIV‐1 Receptor: New Tools to Study Virus–Glycolipid Interactions
Huang et al. Synthesis of (R)-2, 3-epoxypropyl (1→ 3)-β-d-pentaglucoside
Lassaletta et al. Glycosyl Imidates, 75. Synthesis of the Hexasaccharide Moiety of Globo H (Human Breast Cancer) Antigen
CN115920065A (en) Ligand capable of targeting asialoglycoprotein receptor, conjugate and application thereof