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Chakraborty et al., 1994 - Google Patents

Transmission of endogenous VL30 retrotransposons by helper cells used in gene therapy

Chakraborty et al., 1994

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Document ID
7886687400554790217
Author
Chakraborty A
Zink M
Hodgson C
Publication year
Publication venue
Cancer Gene Ther

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Snippet

Retrovirus-derived vectors and packaging cell lines are basic components used for gene transfer in human gene therapy. To eliminate recombinational and transcriptional problems associated with retroviral vectors, synthetic retrotransposon VL30 vectors were devised …
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    • C12N2740/00—Reverse Transcribing RNA Viruses
    • C12N2740/00011—Reverse Transcribing RNA Viruses
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
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    • C12N2830/00—Vector systems having a special element relevant for transcription
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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