[go: up one dir, main page]

Kakeya et al., 2001 - Google Patents

Lucilactaene, a new cell cycle inhibitor in p53-transfected cancer cells, produced by a Fusarium sp.

Kakeya et al., 2001

View PDF
Document ID
7224076753128563045
Author
Kakeya H
Kageyama S
Nie L
Onose R
Okada G
Beppu T
Norbury C
Osada H
Publication year
Publication venue
The Journal of antibiotics

External Links

Snippet

The mycelia obtained from the whole culture broth (30 liters) wereextracted with acetone, whichwasconcentrated in vacuoto removeacetone. Theresulting aqueoussolution wasextracted with ethyl acetate. Theorganic layer was dried over Na2SO4and concentrated …
Continue reading at www.jstage.jst.go.jp (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atom
    • C12P17/08—Oxygen as only ring hetero atom containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—PROCESSES USING MICRO-ORGANISMS
    • C12R1/00—Processes using micro-organisms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00

Similar Documents

Publication Publication Date Title
Kakeya et al. Lucilactaene, a new cell cycle inhibitor in p53-transfected cancer cells, produced by a Fusarium sp.
US7521222B2 (en) Farnesyl dibenzodiazepinone and processes for its production
CN112142585B (en) Mangicols sesterterpene compounds, synthetic method, gene cluster, nucleic acid molecule, construct and application thereof
WO2012010606A1 (en) Hexacyclic polyketides as kinase inhibitors
Kim et al. Penidioxolanes A and B, 1, 3-dioxolane containing azaphilone derivatives from marine-derived Penicillium sp. KCB12C078
US4916065A (en) BU-3420T Antitumor antibiotic
KR0177839B1 (en) Novel thiomarinol derivatives and preparation method thereof
DK170892B1 (en) 14-Oxa-1,11-diazatetracyclo [7.4.1.02,7.010,12] tetra-deca-2,4,6-triene compounds, process for their preparation, pharmaceutical compositions containing the compounds and use of the compounds for the manufacture of drugs and a culture of the microorganism Streptomyces sandaensis
WO2019227969A1 (en) Ansamycin all-carbon cycle polyketide-type antibiotic and uses thereof in preparing antimicrobial medications or anti-tumor medications
PT100365A (en) METHOD FOR PREPARING A NEW IMMUNOSUPPRESS AGENT, WHICH IS A LACTONAMACROCYCLE, FROM STREPTOMYCES BRAEGENSIS
RU2221870C2 (en) Mumbaistatin, method for its preparing and its application as pharmaceutical preparation
JPWO2004078764A1 (en) Antitumor effect potentiator comprising GM-95 substance, antitumor combination preparation and antitumor agent
AU5554400A (en) New indolocarbazole alkaloids from a marine actinomycete
CN111378610B (en) High-yield bafilomycin engineering bacterium and construction and application thereof
CA2538147A1 (en) Farnesyl dibenzodiazepinone, processes for its production and its use as a pharmaceutical
JPH10147594A (en) BE-43547 antitumor substances
JPH06184157A (en) New compound and microbe capable of producing the same
JP2000086627A (en) Antimicrobial substance BE-54476 and method for producing the same
JP2000026497A (en) Antitumor substance BE-60828 and method for producing the same
EP2025758A1 (en) NOVEL ANTIBIOTICS, BISPOLIDES A1, A2 AND A3 AND BISPOLIDES B1, B2a, B2b AND B3 AND METHOD FOR PRODUCING THE ANTIBIOTICS
JPH1121263A (en) BE-45985 antitumor substances
JP2005336088A (en) Thiazole compounds
ZA200504214B (en) Farnesyl dibenzodiazepinones, processes for their production and their use as phamaceuticals
JP2000178274A (en) Antitumor substance BE-54017 and method for producing the same
JPH0987284A (en) Antitumor substance BE-42303