Picco et al., 2024 - Google Patents
Novel WRN helicase inhibitors selectively target microsatellite-unstable cancer cellsPicco et al., 2024
View HTML- Document ID
- 7207175457933965163
- Author
- Picco G
- Rao Y
- Al Saedi A
- Lee Y
- Vieira S
- Bhosle S
- May K
- Herranz-Ors C
- Walker S
- Shenje R
- Dincer C
- Gibson F
- Banerjee R
- Hewitson Z
- Werner T
- Cottom J
- Peng Y
- Deng N
- Zhang Y
- Nartey E
- Nickels L
- Landis P
- Conticelli D
- McCarten K
- Bush J
- Sharma M
- Lightfoot H
- House D
- Milford E
- Grant E
- Glogowski M
- Wagner C
- Bantscheff M
- Rutkowska-Klute A
- Cell Model Network UK Group
- Zappacosta F
- Pettinger J
- Barthorpe S
- Eberl H
- Jones B
- Schneck J
- Murphy D
- Voest E
- Taygerly J
- DeMartino M
- Coelho M
- Houseley J
- Sharma G
- Schwartz B
- Garnett M
- Publication year
- Publication venue
- Cancer discovery
External Links
Snippet
Microsatellite-unstable (MSI) cancers require WRN helicase to resolve replication stress due to expanded DNA (TA) n dinucleotide repeats. WRN is a promising synthetic lethal target for MSI tumors, and WRN inhibitors are in development. In this study, we used CRISPR–Cas9 …
- 206010028980 Neoplasm 0 title abstract description 30
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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