Sharif et al., 2004 - Google Patents
Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulationSharif et al., 2004
View PDF- Document ID
- 6997676727146708612
- Author
- Sharif N
- Drace C
- Williams G
- Crider J
- Publication year
- Publication venue
- Journal of pharmacy and pharmacology
External Links
Snippet
Twenty agonists and nine antagonists were evaluated for their ability to compete for [3H]-8- hydroxy-2-(di-n-propylamino) tetralin ([3H]-8-OH-DPAT) binding to the cloned human serotonin-1A (ch-5-HT1A) receptor expressed in Chinese hamster ovary cells and for their …
- 230000027455 binding 0 title abstract description 65
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
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