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Lääne et al., 1985 - Google Patents

Preparation of polymer‐modified enzymes of prolonged circulation times. Poly [N‐(2‐hydroxypropyl) methacrylamide]‐bound acetylcholinesterase

Lääne et al., 1985

Document ID
6996890500474037158
Author
Lääne A
Aaviksaar A
Haga M
Chytrý V
Kopeček J
Publication year
Publication venue
Die Makromolekulare Chemie: Macromolecular Chemistry and Physics

External Links

Snippet

A covalently bound complex of acetylcholinesterase with poly [N‐(2‐hydroxypropyl) methacrylamide] has been obtained, showing a 70‐fold prolongation of the acetylcholinesterase activity survival in mouse blood after intravenous injection of the …
Continue reading at onlinelibrary.wiley.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
    • A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
    • A61K47/48238—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying agent being a protein, peptide, polyamino acid
    • A61K47/48246—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying agent being a protein, peptide, polyamino acid drug-peptide, protein or polyamino acid conjugates, i.e. the modifying agent being a protein, peptide, polyamino acid which being linked/complexed to a molecule that being the pharmacologically or therapeutically active agent

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Lääne et al. Preparation of polymer‐modified enzymes of prolonged circulation times. Poly [N‐(2‐hydroxypropyl) methacrylamide]‐bound acetylcholinesterase
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