Marek et al., 2018 - Google Patents
Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinantsMarek et al., 2018
View PDF- Document ID
- 6424416104902775218
- Author
- Marek M
- Shaik T
- Heimburg T
- Chakrabarti A
- Lancelot J
- Ramos-Morales E
- Da Veiga C
- Kalinin D
- Melesina J
- Robaa D
- Schmidtkunz K
- Suzuki T
- Holl R
- Ennifar E
- Pierce R
- Jung M
- Sippl W
- Romier C
- Publication year
- Publication venue
- Journal of medicinal chemistry
External Links
Snippet
Metal-dependent histone deacetylases (HDACs) are key epigenetic regulators that represent promising therapeutic targets for the treatment of numerous human diseases. Yet the currently FDA-approved HDAC inhibitors nonspecifically target at least several of the 11 …
- 230000002401 inhibitory effect 0 title abstract description 333
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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