Avichezer et al., 2003 - Google Patents
An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanismsAvichezer et al., 2003
View PDF- Document ID
- 6232131886757466813
- Author
- Avichezer D
- Grajewski R
- Chan C
- Mattapallil M
- Silver P
- Raber J
- Liou G
- Wiggert B
- Lewis G
- Donoso L
- Caspi R
- Publication year
- Publication venue
- The Journal of experimental medicine
External Links
Snippet
Immunologically privileged retinal antigens can serve as targets of experimental autoimmune uveitis (EAU), a model for human uveitis. The tolerance status of susceptible strains, whose target antigen is not expressed in the thymus at detectable levels, is unclear …
- 239000000427 antigen 0 title abstract description 84
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay
- G01N33/564—Immunoassay; Biospecific binding assay for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Avichezer et al. | An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms | |
Fu et al. | Deficiency in T follicular regulatory cells promotes autoimmunity | |
Chen et al. | Where CD4+ CD25+ T reg cells impinge on autoimmune diabetes | |
Smith et al. | Pancreatic gene expression in rare cells of thymic medulla: evidence for functional contribution to T cell tolerance. | |
Caspi | A look at autoimmunity and inflammation in the eye | |
DeVoss et al. | Spontaneous autoimmunity prevented by thymic expression of a single self-antigen | |
Roep et al. | Immune modulation in humans: implications for type 1 diabetes mellitus | |
Chen et al. | Inability of memory T cells to induce graft-versus-host disease is a result of an abortive alloresponse | |
Huseby et al. | Age-dependent T cell tolerance and autoimmunity to myelin basic protein | |
Zhu et al. | Aire deficiency promotes TRP-1–specific immune rejection of melanoma | |
Hayashi | Dysfunction of Lacrimal and Salivary Glands in Sjögren′ s Syndrome: Nonimmunologic Injury in Preinflammatory Phase and Mouse Model | |
Tuncel et al. | T cell anergy in perinatal mice is promoted by T reg cells and prevented by IL-33 | |
Esposito et al. | IL-17–and IFN-γ–secreting Foxp3+ T cells infiltrate the target tissue in experimental autoimmunity | |
Afzali et al. | B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4 | |
Hoehlig et al. | Activation of CD 4+ F oxp3+ regulatory T cells proceeds normally in the absence of B cells during EAE | |
Mencarelli et al. | Calcineurin-mediated IL-2 production by CD11chighMHCII+ myeloid cells is crucial for intestinal immune homeostasis | |
Lambe et al. | Limited peripheral T cell anergy predisposes to retinal autoimmunity | |
Hässler et al. | Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma | |
Proekt et al. | LYN-and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity | |
Taylor et al. | Enhanced tolerance to autoimmune uveitis in CD200-deficient mice correlates with a pronounced Th2 switch in response to antigen challenge | |
van der Touw et al. | NK cells are required for costimulatory blockade induced tolerance to vascularized allografts | |
Malkiel et al. | Autoimmune myocarditis does not require B cells for antigen presentation | |
Thayer et al. | Peripheral proinsulin expression controls low-avidity proinsulin-reactive CD8 T cells in type 1 diabetes | |
Ye et al. | TAM receptor knockout mice are susceptible to retinal autoimmune induction | |
Xu et al. | Regulated tristetraprolin overexpression dampens the development and pathogenesis of experimental autoimmune uveitis |