[go: up one dir, main page]

Winkler et al., 2008 - Google Patents

2′‐O‐Lysylaminohexyl Oligonucleotides: Modifications for Antisense and siRNA

Winkler et al., 2008

Document ID
5784941347866703137
Author
Winkler J
Gilbert M
Kocourková A
Stessl M
Noe C
Publication year
Publication venue
ChemMedChem: Chemistry Enabling Drug Discovery

External Links

Snippet

A novel type of oligonucleotide has been developed, characterized by the attachment of a lysyl moiety to a 2′‐O‐aminohexyl linker. A protected lysine building block was tethered to 2′‐O‐aminohexyluridine, and the product was converted into the corresponding …
Continue reading at chemistry-europe.onlinelibrary.wiley.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Similar Documents

Publication Publication Date Title
US9441228B2 (en) Post-synthetic chemical modification of RNA at the 2′-position of the ribose ring via “click” chemistry
US6914148B2 (en) Guanidinium functionalized intermediates
Griffey et al. 2 ‘-O-Aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides
JPH07502749A (en) Compositions and methods for regulating RNA
US5587469A (en) Oligonucleotides containing N-2 substituted purines
Gautier et al. α-DNA IV: α-anomeric and β-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. Synthesis, physicochemical properties and poly (rA) binding
US20080227742A1 (en) Photocleavable oligonucleotide and uses thereof
WO2008120016A1 (en) Modified nucleic acids
JPH09509435A (en) Novel peptide nucleic acid
KR20100106314A (en) Lipid-modified stranded rna having potent rna interference effect
Deglane et al. Impact of the guanidinium group on hybridization and cellular uptake of cationic oligonucleotides
Winkler et al. 2′‐O‐Lysylaminohexyl Oligonucleotides: Modifications for Antisense and siRNA
Egetenmeyer et al. A 5′‐cap for DNA probes binding RNA target strands
Schmidt et al. Monofunctionally trans‐Diammine Platinum (ii)‐Modified Peptide Nucleic Acid Oligomers: A New Generation of Potential Antisense Drugs
JPH10505354A (en) Functional terpyridine-metal complexes, their preparation and oligonucleotide complexes with terpyridine-metal complexes
US10844376B2 (en) Structurally-enhanced miRNA inhibitor S-TuD
Menzi et al. Towards improved oligonucleotide therapeutics through faster target binding kinetics
Pandolfi et al. Evaluation of different types of end-capping modifications on the stability of oligonucleotides toward 3′-and 5′-exonucleases
Noe et al. Zwitterionic oligonucleotides: a study on binding properties of 2′-O-aminohexyl modifications
Van Daele et al. Triplex Formation by Pyrene‐Labelled Probes for Nucleic Acid Detection in Fluorescence Assays
Hamma et al. Syntheses of alternating oligo-2 ‘-O-methylribonucleoside methylphosphonates and their interactions with HIV TAR RNA
Winkler et al. Oligonucleotides conjugated to short lysine chains
Zubin et al. Oligonucleotides containing 2′-O-[2-(2, 3-dihydroxypropyl) amino-2-oxoethyl] uridine as suitable precursors of 2′-aldehyde oligonucleotides for chemoselective ligation
Kaiser et al. Aminoglycoside–Quinacridine Conjugates: Towards Recognition of the P6. 1 Element of Telomerase RNA
Greco et al. Cytosine-rich oligonucleotides incorporating a non-nucleotide loop: a further step towards the obtainment of physiologically stable i-motif DNA