Snoeck, 2012 - Google Patents

Articaine: a review of its use for local and regional anesthesia

Snoeck, 2012

Document ID: 5611905860318607009
Author: Snoeck M
Publication year: 2012
Publication venue: Local and regional anesthesia

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Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or …

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Classifications

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- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
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Publication	Publication Date	Title
Snoeck	2012	Articaine: a review of its use for local and regional anesthesia
Gitman et al.	2019	Local anesthetic systemic toxicity: a narrative literature review and clinical update on prevention, diagnosis, and management
El-Boghdadly et al.	2018	Local anesthetic systemic toxicity: current perspectives
Gudin et al.	2020	Utility of lidocaine as a topical analgesic and improvements in patch delivery systems
Lönnqvist et al.	2005	Postoperative analgesia in infants and children
Desai et al.	2019	Perineural adjuncts for peripheral nerve block
Park et al.	2017	A review of local anesthetics: minimizing risk and side effects in cutaneous surgery
Shariffuddin et al.	2018	Effect of single-dose dexmedetomidine on postoperative recovery after ambulatory ureteroscopy and ureteric stenting: a double blind randomized controlled study
Xing et al.	2018	Intravenous lidocaine alleviates the pain of propofol injection by local anesthetic and central analgesic effects
Ghodraty et al.	2014	Comparative induction of controlled circulation by magnesium and remifentanil in spine surgery
Tian et al.	2021	Median effective dose of lidocaine for the prevention of pain caused by the injection of propofol formulated with medium-and long-chain triglycerides based on lean body weight
Stringer et al.	2023	Tetracaine
Pan et al.	2020	Dexmedetomidine combined with ropivacaine in ultrasound-guided tranversus abdominis plane block improves postoperative analgesia and recovery following laparoscopic colectomy
Yaster et al.	1994	Local anesthetics in the management of acute pain in children
Rhee et al.	2019	Lipid emulsion therapy of local anesthetic systemic toxicity due to dental anesthesia
Walsh et al.	2011	Local anaesthesia and the dermatologist
Kallio et al.	2006	Hyperbaric articaine for day-case spinal anaesthesia
Kazak et al.	2010	Single dose of preoperative analgesia with gabapentin (600 mg) is safe and effective in monitored anesthesia care for nasal surgery
Seify	2022	Awake plastic surgery procedures: the use of a sufentanil sublingual tablet to improve patient experience
Mahfouz et al.	2002	Preemptive analgesia in rhegmatogenous retinal detachment surgery: is it effective?
Noble	2015	Local anesthesia toxicity and lipid rescue
Wilder	2000	Local anesthetics for the pediatric patient
Giordano et al.	2015	Local anesthesia: evidence, strategies, and safety
Duman et al.	2010	Effects of intrathecal fentanyl on quality of spinal anesthesia in children undergoing inguinal hernia repair
Patel et al.	2014	Pharmacology of local anesthetics

Snoeck, 2012 - Google Patents

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