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Lee et al., 2017 - Google Patents

DNA-catalyzed DNA cleavage by a radical pathway with well-defined products

Lee et al., 2017

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Document ID
5094175121974019960
Author
Lee Y
Klauser P
Brandsen B
Zhou C
Li X
Silverman S
Publication year
Publication venue
Journal of the American Chemical Society

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Snippet

We describe an unprecedented DNA-catalyzed DNA cleavage process in which a radical- based reaction pathway cleanly results in excision of most atoms of a specific guanosine nucleoside. Two new deoxyribozymes (DNA enzymes) were identified by in vitro selection …
Continue reading at pmc.ncbi.nlm.nih.gov (PDF) (other versions)

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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