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Wahlestedt et al., 2013 - Google Patents

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

Wahlestedt et al., 2013

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Document ID
4595053260219309999
Author
Wahlestedt M
Norddahl G
Sten G
Ugale A
Frisk M
Mattsson R
Deierborg T
Sigvardsson M
Bryder D
Publication year
Publication venue
Blood, The Journal of the American Society of Hematology

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Snippet

Aging of hematopoietic stem cells (HSCs) leads to several functional changes, including alterations affecting self-renewal and differentiation. Although it is well established that many of the age-induced changes are intrinsic to HSCs, less is known regarding the stability of this …
Continue reading at www.sciencedirect.com (HTML) (other versions)

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
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    • C12N5/0603—Embryonic cells ; Embryoid bodies
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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