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McLenachan et al., 1991 - Google Patents

Loss of flow-mediated endothelium-dependent dilation occurs early in the development of atherosclerosis.

McLenachan et al., 1991

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Document ID
4374648491683724893
Author
McLenachan J
Williams J
Fish R
Ganz P
Selwyn A
Publication year
Publication venue
Circulation

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Snippet

BACKGROUND Healthy arteries exhibit endothelium-dependent dilation in response to both local acetylcholine and increased blood flow. In humans, clinically overt coronary artery disease is characterized by loss of dilation to both acetylcholine and blood flow. The …
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    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
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