[go: up one dir, main page]

Mendeleyev et al., 1997 - Google Patents

Structural specificity and tumoricidal action of methyl-3, 5-diiodo-4-(4'-methoxyphenoxy) benzoate (DIME)

Mendeleyev et al., 1997

Document ID
4346326425958010889
Author
Mendeleyev J
Young L
Kirsten E
Vidair C
Hakam A
Zhen J
Bauer P
Buki K
Kun E
Publication year
Publication venue
International journal of oncology

External Links

Snippet

Seventeen homologs and analogs of methyl-3, 5-diiodo-4 (4'-methoxyphenoxy) benzoate (DIME), a hormonally inactive analog of thyroid hormones, have been synthesized and their antitumor activity scored by assaying their antitumorigenic effect in vivo following …
Continue reading at www.spandidos-publications.com (other versions)

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/11Aldehydes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/58Unsaturated compounds containing ether groups, groups, groups, or groups

Similar Documents

Publication Publication Date Title
US6017958A (en) Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
US5736576A (en) Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
US8389544B2 (en) Isoquinolone compounds as subtype-selective agonists for melatonin receptors MT1 and MT2
Meyskens Jr et al. Inhibition of human melanoma colony formation by retinoids
Stogniew et al. Electrophilic reactions of acyl-linked glucuronides. Formation of clofibrate mercapturate in humans.
WO1997046228A9 (en) Method of treating malignant tumors with thyroxine analogues having no significant hormonal activity
SHEN et al. Synthesis and cytotoxicity evaluation of some 8‐hydroxyquinoline derivatives
Polossek et al. 6-Alkyl-12-formylindolo [2, 1-a] isoquinolines. Syntheses, estrogen receptor binding affinities, and stereospecific cytostatic activity
Hecht et al. Potent mammary carcinogenicity in female CD rats of a fjord region diol-epoxide of benzo [c] phenanthrene compared to a bay region diol-epoxide of benzo [a] pyrene
JP2010502644A (en) Treatment methods using WRN binding molecules
KR20170070140A (en) Method for treating cancer
US5015666A (en) Triarylcyclopropanes as antiestrogens and antitumor agents
Bertilsson et al. Stereospecific hydroxylation of nortriptyline in man in relation to interindividual differences in its steady-state plasma level
TW202321240A (en) Salt of GLP-1R agonist compound, and preparation method therefor and pharmaceutical use thereof
Biberger et al. 1-Benzyl-2-phenylindole-and 1, 2-diphenylindole-based antiestrogens. Estimation of agonist and antagonist activities in transfection assays
Marrazzo et al. Antiproliferative activity of phenylbutyrate ester of haloperidol metabolite II [(±)-MRJF4] in prostate cancer cells
Mendeleyev et al. Structural specificity and tumoricidal action of methyl-3, 5-diiodo-4-(4'-methoxyphenoxy) benzoate (DIME)
EP2271332B1 (en) Use of compounds in the treatment of tauopathy
WO2008102397A2 (en) Colchicine derivatives, process for their preparation and use in the medical field
Schneider et al. 2-Phenylindenes. Development of a new mammary tumor-inhibiting antiestrogen by combination of estrogenic side effect-lowering structural elements
Antony et al. In-vitro cell line Models and Assay methods to study the Anti-diabetic Activity
WO2007125196A1 (en) Type 1, 4-naphtoquinone compounds, compositions comprising them and use of these compounds as anti-cancer agents
Đorđević et al. Immunomodulatory activity of marine natural products: Synthesis, spectral characterization and toxicity assessment of natural and related synthetic iodinated tyramides
Nagasawa et al. A note on the deacylation of the carcinogen 2-acetamidofluorene and related compounds by rat liver and intestine
Aoki et al. In situ photoaffinity labeling of the target protein for lembehyne A, a neuronal differentiation inducer