[go: up one dir, main page]

McNally et al., 2008 - Google Patents

Electromechanical unzipping of individual DNA molecules using synthetic sub-2 nm pores

McNally et al., 2008

View PDF
Document ID
3959445672652824504
Author
McNally B
Wanunu M
Meller A
Publication year
Publication venue
Nano letters

External Links

Snippet

Nanopores have recently emerged as high-throughput tools for probing and manipulating nucleic acid secondary structure at the single-molecule level. While most studies to date have utilized protein pores embedded in lipid bilayers, solid-state nanopores offer many …
Continue reading at pmc.ncbi.nlm.nih.gov (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the means of detection
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for mutation or polymorphism detection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis

Similar Documents

Publication Publication Date Title
McNally et al. Electromechanical unzipping of individual DNA molecules using synthetic sub-2 nm pores
Chen et al. Digital data storage using DNA nanostructures and solid-state nanopores
Verschueren et al. Label-free optical detection of DNA translocations through plasmonic nanopores
Plesa et al. Detection of individual proteins bound along DNA using solid-state nanopores
Venta et al. Differentiation of short, single-stranded DNA homopolymers in solid-state nanopores
Branton et al. The potential and challenges of nanopore sequencing
Ivankin et al. Label-free optical detection of biomolecular translocation through nanopore arrays
Kowalczyk et al. Detection of local protein structures along DNA using solid-state nanopores
Singer et al. Electronic barcoding of a viral gene at the single-molecule level
Ayub et al. Individual RNA base recognition in immobilized oligonucleotides using a protein nanopore
Gilboa et al. Single-molecule DNA methylation quantification using electro-optical sensing in solid-state nanopores
Chen et al. Ionic current-based mapping of short sequence motifs in single DNA molecules using solid-state nanopores
Larkin et al. Slow DNA transport through nanopores in hafnium oxide membranes
Kowalczyk et al. Unraveling single-stranded DNA in a solid-state nanopore
Ando et al. Directly observing the motion of DNA molecules near solid-state nanopores
Wang et al. Single-molecule discrimination of labeled DNAs and polypeptides using photoluminescent-free TiO2 nanopores
De Vlaminck et al. Highly parallel magnetic tweezers by targeted DNA tethering
Tsutsui et al. Electrical detection of single methylcytosines in a DNA oligomer
Jin et al. Unzipping kinetics of duplex DNA containing oxidized lesions in an α-hemolysin nanopore
Larkin et al. Reversible positioning of single molecules inside zero-mode waveguides
Wang et al. Current enhancement in solid-state nanopores depends on three-dimensional DNA structure
Cracknell et al. Translocating kilobase RNA through the staphylococcal α-hemolysin nanopore
Krishnakumar et al. Slowing DNA translocation through a nanopore using a functionalized electrode
Beamish et al. Identifying structure in short DNA scaffolds using solid-state nanopores
Beamish et al. Programmable DNA nanoswitch sensing with solid-state nanopores