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Zhao et al., 2018 - Google Patents

Hypoxia with Wharton's jelly mesenchymal stem cell coculture maintains stemness of umbilical cord blood-derived CD34+ cells

Zhao et al., 2018

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Document ID
3885703072883853343
Author
Zhao D
Liu L
Chen Q
Wang F
Li Q
Zeng Q
Huang J
Luo M
Li W
Zheng Y
Liu T
Publication year
Publication venue
Stem Cell Research & Therapy

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Background The physiological approach suggests that an environment associating mesenchymal stromal cells with low O 2 concentration would be most favorable for the maintenance of hematopoietic stem/progenitor cells (HSPCs). To test this hypothesis, we …
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
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    • C12N2533/70—Polysaccharides
    • C12N2533/76—Agarose, agar-agar

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