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Oh et al., 2023 - Google Patents

Inhibition of pyruvate dehydrogenase kinase 4 ameliorates kidney ischemia-reperfusion injury by reducing succinate accumulation during ischemia and preserving …

Oh et al., 2023

Document ID
3720974176149112114
Author
Oh C
Kim M
Lee J
Kim D
Kim I
Park S
Kim Y
Lee K
Lee S
Lim C
Kim M
Lee J
Pagire H
Pagire S
Bae M
Chanda D
Thoudam T
Khang A
Harris R
Ahn J
Jeon J
Lee I
Publication year
Publication venue
Kidney International

External Links

Snippet

Ischemia-reperfusion (IR) injury, a leading cause of acute kidney injury (AKI), is still without effective therapies. Succinate accumulation during ischemia followed by its oxidation during reperfusion leads to excessive reactive oxygen species (ROS) and severe kidney damage …
Continue reading at www.sciencedirect.com (other versions)

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