Cevc, 1992 - Google Patents
Drug-carrier and stability properties of the long-lived lipid vesicles. Cryptosomes, in vitro and in vivoCevc, 1992
- Document ID
- 3611047133353874772
- Author
- Cevc G
- Publication year
- Publication venue
- Journal of Liposome Research
External Links
Snippet
Lipid vesicles composed of phosphatidylcholine and suitable polyoxyethylene-derivat-ives of phosphatidylethanolamine (cryptosomes) remain in circulation 8–10 times longer than standard liposomes after an iv administration in mice. In contrast to previous belief, this …
- 150000002632 lipids 0 title abstract description 55
Classifications
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- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
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- A—HUMAN NECESSITIES
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- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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