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Potenza et al., 2002 - Google Patents

Endothelial cyclo-oxygenase-1 and-2 differentially affect reactivity of mesenteric vascular bed in portal hypertensive rats

Potenza et al., 2002

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Document ID
3542875003041482758
Author
Potenza M
Botrugno O
De Salvia M
Lerro G
Nacci C
Marasciulo F
Andriantsitohaina R
Mitolo-Chieppa D
Publication year

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Expression of constitutive and inducible cyclooxygenase (COX-1, COX-2) and the role of prostanoids were investigated in aorta and mesenteric vascular bed (MVB) from portal vein- ligated rat (PVL) as a model of portal hypertension. Functional experiments were carried out …
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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