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Sparreboom et al., 2006 - Google Patents

Topoisomerase I-targeting drugs

Sparreboom et al., 2006

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Document ID
319635222512565737
Author
Sparreboom A
Zamboni W
Publication year
Publication venue
Cancer Chemotherapy and Biotherapy. Lippincott Williams & Wilkins

External Links

Snippet

DNA topoisomerases are essential enzymes found in all nucleated cells. These enzymes are involved in the regulation of DNA topology and are necessary for the preservation of the integrity of the genetic material during DNA metabolism, including RNA tran-scription, DNA …
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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