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Cohier, 2016 - Google Patents

Neuro-respiratory toxicity of buprenorphine in combination to diazepam or ethanol in the presence or not of naloxone: an experimental rat study of the mechanisms of …

Cohier, 2016

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Document ID
3137572978581510466
Author
Cohier C
Publication year

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Background: Buprenorphine may induce respiratory depression in case of misuse or combination to psychotropic drugs despite ceiling effects. Buprenorphine/naloxone combination was marketed to limit buprenorphine misuse; however its usefulness is not …
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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