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Wu et al., 2012 - Google Patents

AMPA receptors regulate exocytosis and insulin release in pancreatic β cells

Wu et al., 2012

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Document ID
309679386697600053
Author
Wu Z
Zhu L
Zou N
Bombek L
Shao C
Wang N
Wang X
Liang L
Xia J
Rupnik M
Shen Y
Publication year
Publication venue
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Ionotropic glutamate receptors (iGluRs) are expressed in islets and insulinoma cells and involved in insulin secretion. However, the exact roles that iGluRs play in β cells remain unclear. Here, we demonstrated that GluR2‐containing α‐amino‐3‐hydroxy‐5‐methyl‐4 …
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    • G—PHYSICS
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    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • A—HUMAN NECESSITIES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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