Kim et al., 2000 - Google Patents
Pharmacodynamic characterization of hemoglobin-induced vasoactivity in isolated rat thoracic aortaKim et al., 2000
View PDF- Document ID
- 2705917990569014723
- Author
- Kim H
- Greenburg A
- Publication year
- Publication venue
- Journal of Laboratory and Clinical Medicine
External Links
Snippet
The origin and mechanism of vasocontraction observed after vascular exposure to acellular Hbs remain controversial. To help resolve the underlying mechanism, we characterized Hb- induced vasoactivities in terms of Hb purity, heme iron oxidation state, and ligand and …
- 241000700159 Rattus 0 title abstract description 38
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/41—Porphyrin- or corrin-ring-containing peptides
- A61K38/42—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (-N=N-), diazo (=N2), azoxy (>N-O-N< or N(=O)-N<), azido (-N3) or diazoamino (-N=N-N<) compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0026—Blood substitute; Oxygen transporting formulations; Plasma extender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation; Therapies using these preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Vandegriff et al. | MP4, a new nonvasoactive PEG‐Hb conjugate | |
| Gladwin et al. | The biochemistry of nitric oxide, nitrite, and hemoglobin: role in blood flow regulation | |
| Olson et al. | No scavenging and the hypertensive effect of hemoglobin-based blood substitutes | |
| Winslow | MP4, a new nonvasoactive polyethylene glycol–hemoglobin conjugate | |
| Winslow | Cell-free oxygen carriers: scientific foundations, clinical development, and new directions | |
| Patel | Biochemical aspects of the reaction of hemoglobin and NO: implications for Hb-based blood substitutes | |
| US20090232909A1 (en) | Method for determining physiological effects of hemoglobin | |
| Cantu-Medellin et al. | Effects of T-and R-state stabilization on deoxyhemoglobin-nitrite reactions and stimulation of nitric oxide signaling | |
| US6197745B1 (en) | Methods for producing nitrosated hemoglobins and therapeutic uses therefor | |
| Mozzarelli et al. | Chemistry and biochemistry of oxygen therapeutics: from transfusion to artificial blood | |
| Lui et al. | Polyethylene glycol conjugation enhances the nitrite reductase activity of native and cross-linked hemoglobin | |
| EP1015490A1 (en) | No-modified hemoglobins and uses therefor | |
| WO1998034955A9 (en) | No-modified hemoglobins and uses therefor | |
| Kim et al. | Pharmacodynamic characterization of hemoglobin-induced vasoactivity in isolated rat thoracic aorta | |
| US20150306183A1 (en) | Five-coordinate neuroglobin and use thereof as a blood substitute | |
| Kim et al. | Ferrrous hemoglobin scavenging of endothelium derived nitric oxide is a principal mechanism for hemoglobin mediated vasoactivities in isolated rat thoracic aorta | |
| Abali et al. | Lippincott illustrated reviews: biochemistry | |
| Morgan et al. | Binding and transport of iron-porphyrins by hemopexin | |
| Scatena et al. | O-raffinose-polymerised haemoglobin. A biochemical and pharmacological profile of an oxygen carrier | |
| Wang et al. | Cross‐linked hemoglobin bis‐tetramers from bioorthogonal coupling do not induce vasoconstriction in the circulation | |
| Deem | Nitric oxide scavenging by hemoglobin regulates hypoxic pulmonary vasoconstriction | |
| Rajko Igić et al. | Removal of Arg141 from the α chain of human hemoglobin by carboxypeptidases N and M | |
| Coleman | Hemoglobin metabolism | |
| Wang | Acetylated Hemoglobin Bis-Tetramers: From Chemical Designs to Physiological Impacts | |
| Shen et al. | Nitric Oxide and Hemoglobin: Physiological Implications |