[go: up one dir, main page]

Ajasin et al., 2019 - Google Patents

CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release

Ajasin et al., 2019

View HTML
Document ID
270352592946291117
Author
Ajasin D
Rao V
Wu X
Ramasamy S
Pujato M
Ruiz A
Fiser A
Bresnick A
Kalpana G
Prasad V
Publication year
Publication venue
Elife

External Links

Snippet

Cellular ESCRT machinery plays pivotal role in HIV-1 budding and release. Extracellular stimuli that modulate HIV-1 egress are currently unknown. We found that CCL2 induced by HIV-1 clade B (HIV-1B) infection of macrophages enhanced virus production, while CCL2 …
Continue reading at elifesciences.org (HTML) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse Transcribing RNA Viruses
    • C12N2740/00011—Reverse Transcribing RNA Viruses
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriphage
    • C12Q1/701—Specific hybridization probes
    • C12Q1/702—Specific hybridization probes for retroviruses
    • C12Q1/703—Viruses associated with AIDS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus

Similar Documents

Publication Publication Date Title
Ajasin et al. CCL2 mobilizes ALIX to facilitate Gag-p6 mediated HIV-1 virion release
Lahaye et al. NONO detects the nuclear HIV capsid to promote cGAS-mediated innate immune activation
Usami et al. SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef
Barr et al. The interferon response inhibits HIV particle production by induction of TRIM22
Sharova et al. Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction
Klockow et al. The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection
Pontow et al. Actin cytoskeletal reorganizations and coreceptor-mediated activation of rac during human immunodeficiency virus-induced cell fusion
Valera et al. The HDAC6/APOBEC3G complex regulates HIV-1 infectiveness by inducing Vif autophagic degradation
Carthagena et al. Implication of TRIMalpha and TRIMCyp in interferon-induced anti-retroviral restriction activities
Khan et al. HIV-1 Vpr antagonizes innate immune activation by targeting karyopherin-mediated NF-κB/IRF3 nuclear transport
Yin et al. Equine tetherin blocks retrovirus release and its activity is antagonized by equine infectious anemia virus envelope protein
Höhne et al. Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection
Martin et al. APOBEC3G complexes decrease human immunodeficiency virus type 1 production
Zhou et al. The HIV-1 accessory protein Vpr induces the degradation of the anti-HIV-1 agent APOBEC3G through a VprBP-mediated proteasomal pathway
Henao-Mejia et al. Suppression of HIV-1 Nef translation by Sam68 mutant-induced stress granules and nef mRNA sequestration
Dwivedi et al. HIV-1 capsid and viral DNA integration
Yi et al. Host ZCCHC3 blocks HIV-1 infection and production through a dual mechanism
Xiong et al. C19ORF66 is an interferon-stimulated gene (ISG) which Inhibits human immunodeficiency virus-1
Kim et al. Identification of a novel type of small molecule inhibitor against HIV-1
Stevenson CROI 2016: Basic science review
Tamburello Functional analysis of interaction between primary HIV-1 nef alleles and host proteins
Van Duyne et al. Retroviral proteomics and interactomes: intricate balances of cell survival and viral replication
Rezaei et al. Ectopic USP15 expression inhibits HIV-1 transcription involving changes in YY1 deubiquitination and stability
Bunten Host Cell Peptidylprolyl cis-trans Isomerases as Immune Modulators of HIV-1 Infection
Castro Understanding the mutual antagonism between HIV and autophagy