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Kim et al., 2005 - Google Patents

Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT

Kim et al., 2005

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Document ID
1874751756507778787
Author
Kim J
Park S
Kang M
Oh S
Lee T
Muller M
Chung I
Publication year
Publication venue
Genes & development

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Snippet

Telomere homeostasis is regulated by telomerase and a collection of associated proteins. Telomerase is, in turn, regulated by post-translational modifications of the rate-limiting catalytic subunit hTERT. Here we show that disruption of Hsp90 by geldanamycin promotes …
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