[go: up one dir, main page]

Ng et al., 2010 - Google Patents

Clostridium difficile toxin–induced inflammation and intestinal injury are mediated by the inflammasome

Ng et al., 2010

View HTML
Document ID
1872340851466582111
Author
Ng J
Hirota S
Gross O
Li Y
Ulke–Lemee A
Potentier M
Schenck L
Vilaysane A
Seamone M
Feng H
Armstrong G
Tschopp J
MacDonald J
Muruve D
Beck P
Publication year
Publication venue
Gastroenterology

External Links

Snippet

BACKGROUND & AIMS: Clostridium difficile–associated disease (CDAD) is the leading cause of nosocomial diarrhea in the United States. C difficile toxins TcdA and TcdB breach the intestinal barrier and trigger mucosal inflammation and intestinal damage. The …
Continue reading at www.gastrojournal.org (HTML) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Micro-organisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Similar Documents

Publication Publication Date Title
Ng et al. Clostridium difficile toxin–induced inflammation and intestinal injury are mediated by the inflammasome
Ke et al. Type IV secretion system of Brucella spp. and its effectors
Guiney et al. The role of the spv genes in Salmonella pathogenesis
Popoff Epsilon toxin: a fascinating pore‐forming toxin
Sun et al. A family of Salmonella type III secretion effector proteins selectively targets the NF-κB signaling pathway to preserve host homeostasis
Ma et al. Citrobacter rodentium infection causes both mitochondrial dysfunction and intestinal epithelial barrier disruption in vivo: role of mitochondrial associated protein (Map)
Liao et al. Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells
Ahmer et al. Salmonella SirA is a global regulator of genes mediating enteropathogenesis
Zhou et al. Molecular and physiological insights into plague transmission, virulence and etiology
Crouch et al. The alternative sigma factor σE is required for resistance of Salmonella enterica serovar Typhimurium to anti‐microbial peptides
Wall et al. Identification of the Salmonella enterica serotype typhimurium SipA domain responsible for inducing neutrophil recruitment across the intestinal epithelium
Callegan et al. Bacillus endophthalmitis: roles of bacterial toxins and motility during infection
Fischer et al. Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori
Banks et al. New insights into the functions of anthrax toxin
Reffuveille et al. The prolipoprotein diacylglyceryl transferase (Lgt) of Enterococcus faecalis contributes to virulence
Cho et al. Involvement of lipoprotein P pi A of S treptococcus gordonii in evasion of phagocytosis by macrophages
Ke et al. Inhibition of TLR4 signaling by Brucella TIR-containing protein TcpB-derived decoy peptides
Cash Drug and vaccine development for Neisseria gonorrhoeaea
Jean Characterizarion of the Regulation and Function of Neisseria Gonorrhoeae TonB-Dependent Transporters: TdfG, TdfH and TdfJ
Klappenbach Trigger Signaling Through Host Cell Focal Adhesions to Inhibit Cell Motility and Impede Wound Repair
Cai Modulation of Inflammasome Signaling During Chronic Bacterial Infections
Badilla Pathogenic contributions of Clostridium perfringens enterotoxin and NanI sialidase to intestinal disease in murine models
Scott Characterisation of the Metabolic Phenotype of the Fmo5 Knockout Mouse
Prange A cigarette smoke induced Drosophila model identifies molecular mechanisms underlying COPD development
Lester HcpE, a potential immuno-modulatory protein from Helicobacter pylori that is dependent on the Disulfide bond protein DsbHP