[go: up one dir, main page]

Sargsyan et al., 2024 - Google Patents

Modeling, synthesis and in vitro testing of peptides based on unusual amino acids as potential antibacterial agents

Sargsyan et al., 2024

View PDF
Document ID
1868146216482138623
Author
Sargsyan A
Karapetyan L
Mkhitaryan A
Stepanyan L
Sargsyan T
Danghyan Yu M
Sargsyan A
Oganezova G
Hovhannisyan N
Publication year
Publication venue
Biomeditsinskaya khimiya

External Links

Snippet

Currently non-protein amino acids and synthetic peptides are widely used as blocks in drug design. Many proteases are of great interest for pharmacology due to their key role in various pathologies. Bacterial collagenase (EC 3.4. 24.3) is quite an attractive target for drug …
Continue reading at pbmc.ibmc.msk.ru (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Similar Documents

Publication Publication Date Title
Chen et al. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi
Zhulenkovs et al. Discovery and structure–activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase
Needham et al. Drug targeting to monocytes and macrophages using esterase-sensitive chemical motifs
US20110275635A1 (en) Small molecule inhibitors of nads, namnat, and nmnat
Sargsyan et al. Modeling, synthesis and in vitro testing of peptides based on unusual amino acids as potential antibacterial agents
AU2007277253A1 (en) Bisfuranyl protease inhibitors
Salmi-Smail et al. Modified cap group suberoylanilide hydroxamic acid histone deacetylase inhibitor derivatives reveal improved selective antileukemic activity
Lee et al. Discovery of novel selective inhibitors of Staphylococcus aureus β-ketoacyl acyl carrier protein synthase III
Singh et al. Antiplasmodial activity of hydroxyethylamine analogs: synthesis, biological activity and structure activity relationship of plasmepsin inhibitors
Li et al. Identification of novel 4-substituted 7H-pyrrolo [2, 3-d] pyrimidine derivatives as new FtsZ inhibitors: Bioactivity evaluation and computational simulation
Hattori et al. Solution-phase synthesis and biological evaluation of triostin A and its analogues
Kurisawa et al. Isolation and total synthesis of kinenzoline, an antitrypanosomal linear depsipeptide isolated from a marine Salileptolyngbya sp. cyanobacterium
Spork et al. Analogues of muraymycin nucleoside antibiotics with epimeric uridine-derived core structures
Bangalore et al. Aryl-n-hexanamide linked enaminones of usnic acid as promising antimicrobial agents
Thangavelu et al. Synthesis, evaluation and docking studies of novel formazan derivatives as an enoyl-ACP reductase inhibitors
Sargsyan et al. The synthesis and in vitro study of 9-fluorenylmethoxycarbonyl protected non-protein amino acids antimicrobial activity
Liveris et al. Synthesis and characterization of the N-succinyl-l, l-diaminopimelic acid desuccinylase (DapE) alternate substrate analog N, N-dimethyl-l, l-SDAP
CN110028477B (en) Preparation method and application of 4-site split nitrogen mustard derivatives of brefeldin A
Qu et al. Design, synthesis, and antibacterial activity of novel 8-methoxyquinoline-2-carboxamide compounds containing 1, 3, 4-thiadiazole moiety
US11773127B2 (en) Compounds and methods for treating bacterial infections
CN110028478B (en) Preparation method and application of a class of brefeldin A 4,7-position spliced nitrogen mustard derivatives
Li et al. A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine
Deng et al. Synthesis, evaluation of anti-Toxoplasma gondii activity in vitro and molecular docking of dihydroartemisinin derivatives
Ajima et al. Synthesis, characterization and biological evaluation of benzimidazole-dihydroartemisinin hybrids as potential dual acting antimalarial agents
Elumalai et al. Development of potent cholinesterase inhibitors based on a marine pharmacophore