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Hennessy et al., 2024 - Google Patents

Thiazole orange-carboplatin triplex-forming oligonucleotide (TFO) combination probes enhance targeted DNA crosslinking

Hennessy et al., 2024

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Document ID
1863688607563190989
Author
Hennessy J
Klimkowski P
Singleton D
Gibney A
Coche M
Farrell N
El-Sagheer A
Brown T
Kellett A
Publication year
Publication venue
RSC Medicinal Chemistry

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Snippet

We report a new class of carboplatin-TFO hybrid that incorporates a bifunctional alkyne– amine nucleobase monomer called AP-C3-dT that enables dual 'click'platinum (II) drug conjugation and thiazole orange fluorophore coupling. Thiazole orange enhances the …
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the means of detection
    • C12Q1/6818—Hybridisation assays characterised by the means of detection involving interaction of at least two labels, e.g. resonant energy transfer
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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    • C12N2310/00—Structure or type of the nucleic acid
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