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Gupta et al., 2015 - Google Patents

Polymeric drug-delivery systems: role in P-gp efflux system inhibition

Gupta et al., 2015

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Document ID
1749680548135894866
Author
Gupta P
Garg T
Tanmay M
Arora S
Publication year
Publication venue
Critical Reviews™ in Therapeutic Drug Carrier Systems

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ABSTRACT Permeability glycoprotein (P-gp), a multispecific drug transporter belonging to the multidrug resistance (MDR) gene subfamily, is mainly responsible for efflux of diffused intracellular drugs, resulting in poor drug bioavailability. P-gp is overexpressed in the blood …
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
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