[go: up one dir, main page]

Naguib et al., 1995 - Google Patents

Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii

Naguib et al., 1995

Document ID
17416201313946010069
Author
Naguib F
Iltzsch M
El Kouni M
Panzica R
El Kouni M
Publication year
Publication venue
Biochemical pharmacology

External Links

Snippet

Preliminary characterization of Toxoplasma gondii phosphoribosyltransferase activity towards purine nucleobases indicates that there are at least two enzymes present in these parasites. One enzyme uses hypoxanthine, guanine, and xanthine as substrates, while a …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Similar Documents

Publication Publication Date Title
Iltzsch et al. Structure-activity relationship for the binding of nucleoside ligands to adenosine kinase from Toxoplasma gondii
Aronow et al. Two high affinity nucleoside transporters in Leishmania donovani
Stone et al. Purines: basic and clinical aspects
Prichard et al. Strategic design and three-dimensional analysis of antiviral drug combinations
Krenitsky et al. Inhibition of human purine nucleoside phosphorylase: studies with intact erythrocytes and the purified enzyme
Wang et al. Purine salvage by Tritrichomonas foetus
Daly Alkylxanthines as research tools
Naguib et al. Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyltransferase from Toxoplasma gondii
Hartman et al. Inhibitors of IMP dehydrogenase stimulate the phosphorylation of the anti-human immunodeficiency virus nucleosides 2', 3'-dideoxyadenosine and 2', 3'-dideoxyinosine.
CA2231442A1 (en) Therapeutic azide compounds
Hill Hypoxanthine phosphoribosyltransferase and guanine metabolism of adenocarcinoma 755 cells
Wang et al. Characterization of human, dog and rabbit corpus cavernosum type 5 phosphodiesterases
Fabianowska-Majewska et al. Effects of novel anti-viral adenosine analogues on the activity of S-adenosylhomocysteine hydrolase from human liver
Niedzwicki et al. Structure-activity relationship of ligands of human plasma adenosine deaminase2
Davies et al. Stimulation of guinea-pig brain adenylate cyclase by adenosine analogues with potent pharmacological activity in vivo
Vesely B complex vitamins activate rat guanylate cyclase and increase cyclic GMP levels
Chheda et al. N6-(Δ2-isopentenyl) adenosine metabolism in man
US5773424A (en) Treatment of toxoplasmosis
Carson et al. Deoxyadenosine-resistant human T lymphoblasts with elevated 5′-nucleotidase activity
Mills et al. Urinary excretion of purines, purine nucleosides, and pseudouridine in adenosine deaminase deficiency
Simmonds et al. Purine and pyrimidine metabolism in hereditary orotic aciduria: some unexpected effects of allopurinol
Elion Actions of purine analogs: enzyme specificity studies as a basis for interpretation and design
Jadhav et al. Inhibition of hypoxanthine-guanine phosphoribosyl transferase
Nolan et al. Caffeine: its action on purine metabolizing enzymes
Sarup et al. Regulation of purine deoxynucleoside phosphorylation by deoxycytidine kinase from human leukemic blast cells