[go: up one dir, main page]

Gee, 1988 - Google Patents

Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore

Gee, 1988

Document ID
17254456300532409249
Author
Gee K
Publication year
Publication venue
Molecular Neurobiology

External Links

Snippet

Recent findings suggest that steroids with sedative-hypnotic properties interact specifically with the γ-aminobutyric acidA/benzodiazepine receptor-chloride ionophore complex (GBRC). They show positive heterotropic cooperativity by allosterically enhancing the …
Continue reading at link.springer.com (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9406—Neurotransmitters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/88—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving prostaglandins or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone

Similar Documents

Publication Publication Date Title
Gee Steroid modulation of the GABA/benzodiazepine receptor-linked chloride lonophore
Belelli et al. Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex
Rupprecht et al. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology
Turner et al. Steroid anesthetics and naturally occurring analogs modulate the gamma-aminobutyric acid receptor complex at a site distinct from barbiturates.
Picazo et al. Anti-anxiety effects of progesterone and some of its reduced metabolites: an evaluation using the burying behavior test
Morrow et al. Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action?
Gilfarb et al. GABA system modifications during periods of hormonal flux across the female lifespan
Smith Withdrawal properties of a neuroactive steroid: implications for GABAA receptor gene regulation in the brain and anxiety behavior
Gee et al. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.
Follesa et al. Role of allopregnanolone in regulation of GABAA receptor plasticity during long-term exposure to and withdrawal from progesterone
Lan et al. Differential responses of expressed recombinant human γ‐aminobutyric acidA receptors to neurosteroids
Matsumoto et al. Social isolation stress-induced aggression in mice: a model to study the pharmacology of neurosteroidogenesis
Turkmen et al. Tolerance to allopregnanolone with focus on the GABA‐A receptor
Smith et al. Steroid withdrawal in the mouse results in anxiogenic effects of 3α, 5β-THP: a possible model of premenstrual dysphoric disorder
Spigelman et al. Behavior and physiology of mice lacking the GABAA‐receptor δ subunit
Majewska Antagonist-type interaction of glucocorticoids with the GABA receptor-coupled chloride channel
Thomas et al. Anti-apoptotic actions of allopregnanolone and ganaxolone mediated through membrane progesterone receptors (PAQRs) in neuronal cells
Morris et al. Differential modulation of the γ-aminobutyric acid type C receptor by neuroactive steroids
WO1993005786A1 (en) Novel gabaa receptor with steroid binding sites
Maitra et al. Subunit dependent modulation of GABAA receptor function by neuroactive steroids
Davis et al. Developmental switch in the expression of GABAA receptor subunits α1 and α2 in the hypothalamus and limbic system of the rat
Frye et al. Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3α, 5α-THP-facilitated lordosis
King Neurosteroids and the nervous system
Orchinik et al. Steroid modulation of GABAA receptors in an amphibian brain
Birzniece et al. GABAA receptor changes in acute allopregnanolone tolerance