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Dharia et al., 2021 - Google Patents

A first-generation pediatric cancer dependency map

Dharia et al., 2021

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Document ID
16886008896398013674
Author
Dharia N
Kugener G
Guenther L
Malone C
Durbin A
Hong A
Howard T
Bandopadhayay P
Wechsler C
Fung I
Warren A
Dempster J
Krill-Burger J
Paolella B
Moh P
Jha N
Tang A
Montgomery P
Boehm J
Hahn W
Roberts C
McFarland J
Tsherniak A
Golub T
Vazquez F
Stegmaier K
Publication year
Publication venue
Nature genetics

External Links

Snippet

Exciting therapeutic targets are emerging from CRISPR-based screens of high mutational- burden adult cancers. A key question, however, is whether functional genomic approaches will yield new targets in pediatric cancers, known for remarkably few mutations, which often …
Continue reading at pmc.ncbi.nlm.nih.gov (HTML) (other versions)

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Hybridisation probes
    • C12Q1/6883—Hybridisation probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Hybridisation probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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