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Salas-Lloret et al., 2023 - Google Patents

BRCA1/BARD1 ubiquitinates PCNA in unperturbed conditions to promote replication fork stability and continuous DNA synthesis

Salas-Lloret et al., 2023

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Document ID
16874347125348547823
Author
Salas-Lloret D
García-Rodríguez N
Giebel L
de Ru A
van Veelen P
Huertas P
Vertegaal A
González-Prieto R
Publication year
Publication venue
bioRxiv

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Snippet

Deficiencies in the BRCA1 tumor suppressor gene are the main cause of hereditary breast and ovarian cancer. BRCA1 is involved in the Homologous Recombination DNA repair pathway, and, together with BARD1, forms a heterodimer with ubiquitin E3 activity. The …
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