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Gillam et al., 1997 - Google Patents

Expression of Cytochrome P450 3A7 inEscherichia coli: Effects of 5′ Modification and Catalytic Characterization of Recombinant Enzyme Expressed in Bicistronic …

Gillam et al., 1997

Document ID
16731313581040092803
Author
Gillam E
Wunsch R
Ueng Y
Shimada T
Reilly P
Kamataki T
Guengerich F
Publication year
Publication venue
Archives of biochemistry and biophysics

External Links

Snippet

Cytochrome P450 3A7 is the major P450 form present in fetal liver tissue and may be responsible for the detoxification of many drugs that reach the fetal circulation. We report the development of bacterial expression systems for P450 3A7. Maximal yields (up to 50 nmol …
Continue reading at www.sciencedirect.com (other versions)

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
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