[go: up one dir, main page]

Hyndiuk et al., 1976 - Google Patents

Treatment of vaccinial keratitis with trifluorothymidine

Hyndiuk et al., 1976

Document ID
16522837061893994785
Author
Hyndiuk R
Seideman S
Leibsohn J
Publication year
Publication venue
Archives of Ophthalmology

External Links

Snippet

• The efficacy of trifluorothymidine was compared with idoxuridine on a blind basis by noting the effect of topical administration of the drugs on the severity of vaccinial keratitis induced in rabbits. Trifluorothymidine was found to be substantially more effective, and was well …
Continue reading at jamanetwork.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens

Similar Documents

Publication Publication Date Title
Pavan-Langston et al. A double blind clinical study of adenine arabinoside therapy of viral keratoconjunctivitis
Park et al. Acyclovir in oral and ganglionic herpes simplex virus infections
Chou et al. Controlled clinical trial of intravenous acyclovir in heart-transplant patients with mucocutaneous herpes simplex infections
Hopen et al. Corneal toxicity with systemic cytarabine
Klein Pathogenetic mechanisms of recurrent herpes simplex virus infections
Maudgal et al. Topical treatment of experimental herpes simplex keratouveitis with 2′-O-glycylacyclovir: A water-soluble ester of acyclovir
Sklar et al. Herpes zoster: the treatment and prevention of neuralgia with adenosine monophosphate
EP0109234B1 (en) Compositions comprising interferon and their therapeutic use
Davis et al. Relapsing herpes simplex encephalitis following antiviral therapy
Hyndiuk et al. Treatment of vaccinial keratitis with trifluorothymidine
Colin et al. Combination therapy for dendritic keratitis with human leukocyte interferon and acyclovir
Maudgal et al. Experimental stromal herpes simplex keratitis: Influence of treatment with topical bromovinyldeoxyuridine and trifluridine
Pavan-Langston et al. Herpetic ganglionic latency: aciclovir and vidarabine therapy
US4603122A (en) Antiviral agent against herpes virus infections
Maudgal et al. Oral and topical treatment of experimental herpes simplex iritis with bromovinyldeoxyuridine
Romanowski et al. Comparative antiviral efficacies of cidofovir, trifluridine, and acyclovir in the HSV-1 rabbit keratitis model.
Hill et al. Adrenergically induced recurrent HSV-1 corneal epithelial lesions
Pavan-Langston et al. Ganglionic herpes simplex and systemic acyclovir
Hyndiuk et al. Treatment of vaccinial keratitis with vidarabine
Surman et al. A double-blind, placebo-controlled study of oral acyclovir in postherpetic neuralgia
Gordon et al. The role of herpesvirus type 1 thymidine kinase in experimental ocular infections
Trousdale et al. Assessment of acyclovir on acute ocular infection induced by drug-resistant strains of HSV-1.
Smith et al. Experimental Ocular Herpetic Infections in Rabbits: Treatment With 9-([2-Hydroxy-1-(hydroxymethyl) ethoxy] methyl) guanine
Hill et al. Acyclovir and vidarabine monophosphate: Comparison of lontophoretic and intravenous administration for the treatment of HSV-1 stromal keratitis
Loeffel et al. Eczema vaccinatum in Darier's disease