Abdel-Atty et al., 2014 - Google Patents
Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agentsAbdel-Atty et al., 2014
View PDF- Document ID
- 16200409166206411963
- Author
- Abdel-Atty M
- Farag N
- Kassab S
- Serya R
- Abouzid K
- Publication year
- Publication venue
- Bioorganic Chemistry
External Links
Snippet
In this study, five series of (E)-6-(4-substituted phenyl)-4-oxohex-5-enoic acids IIb–f (E),(E)-3- (4-(substituted)-phenyl) acrylic acids IIIa–g (E), 4-(4-(substituted) phenylamino)-4- oxobutanoic acids VIa, b, e, 5-(4-(substituted) phenylamino)-5-oxopentanoic acids VIIa, f …
- 238000004617 QSAR study 0 title abstract description 30
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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