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Schaefer et al., 2017 - Google Patents

MAX inactivation is an early event in GIST development that regulates p16 and cell proliferation

Schaefer et al., 2017

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Document ID
1597340098350945654
Author
Schaefer I
Wang Y
Liang C
Bahri N
Quattrone A
Doyle L
Mariño-Enríquez A
Lauria A
Zhu M
Debiec-Rychter M
Grunewald S
Hechtman J
Dufresne A
Antonescu C
Beadling C
Sicinska E
Van De Rijn M
Demetri G
Ladanyi M
Corless C
Heinrich M
Raut C
Bauer S
Fletcher J
Publication year
Publication venue
Nature communications

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Snippet

Abstract KIT, PDGFRA, NF1 and SDH mutations are alternate initiating events, fostering hyperplasia in gastrointestinal stromal tumours (GISTs), and additional genetic alterations are required for progression to malignancy. The most frequent secondary alteration …
Continue reading at www.nature.com (HTML) (other versions)

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
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    • C12Q1/6876—Hybridisation probes
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