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Yamamoto et al., 2000 - Google Patents

Molecular beacon aptamer fluoresces in the presence of Tat protein of HIV‐1

Yamamoto et al., 2000

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Document ID
15794825907539272125
Author
Yamamoto R
Kumar P
Publication year
Publication venue
Genes to cells

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Background We reported an aptamer, RNATat that binds to the Tat protein of HIV with two orders of magnitude greater (133‐fold) affinity over the TAR RNA of HIV‐1 and specifically inhibits the Tat‐dependent trans‐activation of transcription, both in vitro and in vivo …
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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