Fremond et al., 1993 - Google Patents
Correction of bilirubin conjugation in the Gunn rat using hepatocytes immobilized in alginate gel beads as an extracorporeal bioartificial liverFremond et al., 1993
- Document ID
- 14656399524216020500
- Author
- Fremond B
- Malandain C
- Guyomard C
- Chesne C
- Guillouzo A
- Campion J
- Publication year
- Publication venue
- Cell transplantation
External Links
Snippet
A new extracorporeal bioartificial liver using alginate-entrapped hepatocytes was developed and evaluated for its ability to correct the lack of bilirubin conjugation in the Gunn rat. Hepatocytes were harvested from Sprague-Dawley rats by the two-step collagenase …
- 210000003494 Hepatocytes 0 title abstract description 75
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/02—Enzymes or microbial cells being immobilised on or in an organic carrier
- C12N11/04—Enzymes or microbial cells being immobilised on or in an organic carrier entrapped within the carrier, e.g. gel, hollow fibre
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
- C12N11/14—Enzymes or microbial cells being immobilised on or in an inorganic carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration
- A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. haemofiltration, diafiltration with treatment of the filtrate
- A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
- A61M1/3489—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents by biological cells
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Fremond et al. | Correction of bilirubin conjugation in the Gunn rat using hepatocytes immobilized in alginate gel beads as an extracorporeal bioartificial liver | |
| EP0817833B1 (en) | Filter device | |
| US6858146B1 (en) | Artificial liver apparatus and method | |
| US20220098548A1 (en) | Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same | |
| Strom et al. | Hepatocyte transplantation as a bridge to orthotopic liver transplantation in terminal liver failure | |
| ES2227607T3 (en) | SOLID SUPPORT FOR USE IN CELL CULTURE, ESPECIALLY FOR THE CULTURE OF HEPATIC CELLS, BIOLOGICAL REACTOR CONTAINING SUCH SOLID SUPPORT AND ITS USE IN A BIOARTIFICIAL LIVER SYSTEM. | |
| MAKI et al. | Successful treatment of diabetes with the biohybrid artificial pancreas in dogs | |
| Rozga et al. | Isolated hepatocytes in a bioartificial liver: a single group view and experience | |
| WO1992007615A1 (en) | A bioartificial liver | |
| US20150073389A1 (en) | Differentiated human liver cell cultures and their use in bioartificial liver systems | |
| WO2003105663A2 (en) | Liver assist system based on hollow fiber cartridges or rotating bioreactor | |
| Dixit et al. | Artificial liver support: state of the art | |
| Iwata et al. | In vitro evaluation of metabolic functions of a bioartificial liver | |
| Kumar et al. | Extracorporeal bioartificial liver for treating acute liver diseases | |
| Jauregui et al. | Use of mammalian liver cells for artificial liver support | |
| Rozga et al. | Artificial liver evolution and future perspectives | |
| Mundt et al. | A method to assess biochemical activity of liver cells during clinical application of extracorporeal hybrid liver support | |
| Morsiani et al. | In VitroMorphological and Functional Characterization of Isolated Porcine Hepatocytes for Extracorporeal Liver Support: Bile Acid Uptake and Conjugation | |
| Stefanovich et al. | Extracorporeal plasma perfusion of cultured hepatocytes: effect of intermittent perfusion on hepatocyte function and morphology | |
| Matthew et al. | Performance of plasma-perfused, microencapsulated hepatocytes: prospects for extracorporeal liver support | |
| KR20080088817A (en) | Bioartificial Systems Using Gel Bead Filled Bioreactors | |
| Flendrig et al. | Does the extend of the culture time of primary hepatocytes in a bioreactor affect the treatment efficacy of a bioartificial liver? | |
| Chang | [46] Methods for the therapeutic applications of immobilized enzymes | |
| Raghavan et al. | Degradation of oxalate in rats implanted with immobilized oxalate oxidase | |
| Sauer et al. | Lactate release and uptake in hepatoma 7288CTC perfused in situ with L-[(U)-14C] lactate or D-[(U)-14C] glucose |