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Skinner et al., 2003 - Google Patents

Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers

Skinner et al., 2003

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Document ID
13942363083203428267
Author
Skinner M
Kuan H
Pan A
Sathirakul K
Knadler M
Gonzales C
Yeo K
Reddy S
Lim M
Ayan‐Oshodi M
Wise S
Publication year
Publication venue
Clinical Pharmacology & Therapeutics

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Background and Objectives Duloxetine, a potent dual reuptake inhibitor of serotonin and norepinephrine currently undergoing clinical investigation for treatment of depression and stress urinary incontinence, has the potential to act as both a substrate and an inhibitor of …
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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