[go: up one dir, main page]

Von Niederhäusern et al., 1993 - Google Patents

Cloning and expression in mammalian cells of porcine tumor necrosis factor alpha: examination of biological properties

Von Niederhäusern et al., 1993

Document ID
12599893867538831889
Author
Von Niederhäusern B
Bertoni G
Hertig C
Pfister H
Peterhans E
Pauli U
Publication year
Publication venue
Veterinary immunology and immunopathology

External Links

Snippet

We have cloned a full length complementary DNA (cDNA) of the porcine tumor necrosis factor α (pTNF-α) gene and expressed it in porcine and murine cells. Total RNA obtained from lipopolysaccharide (LPS) stimulated porcine peripheral blood mononuclear cells was …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumor necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55522—Cytokines; Lymphokines; Interferons
    • A61K2039/55527—Interleukins

Similar Documents

Publication Publication Date Title
JP2557341B2 (en) Tumor necrosis factor
Leutz et al. Molecular cloning of the chicken myelomonocytic growth factor (cMGF) reveals relationship to interleukin 6 and granulocyte colony stimulating factor.
FI86885C (en) Method for Preparation of Human Recombinant Factor VIII and Nucleic Acid Sequences and Vectors Used thereto
EP1987845B1 (en) Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor.
CN103403166B (en) Novel hybrid promoter and recombinant vector comprising the same
JP2721139B2 (en) Animal interferon
PT92479A (en) PROCESS OF PREPARATION OF RECOMBINANT GENES AND ITS CODING PROTEINS
Von Niederhäusern et al. Cloning and expression in mammalian cells of porcine tumor necrosis factor alpha: examination of biological properties
Morsey et al. Molecular cloning and expression of bovine interleukin-8
AU2009248735B2 (en) Expression vector encoding alphavirus replicase and the use thereof as immunological adjuvant
Takakuwa et al. Induction of CD14 expression in Lpsn, Lpsd and tumor necrosis factor receptor‐deficient mice
CA2041638C (en) Recombinant polynucleotide constructs suitable for providing secretion of pai-2
Green et al. A comparison of the anti-luteolytic activities of recombinant ovine interferon-alpha and-tau in sheep
Ebrahimi et al. Cloning, sequencing and expression of the ovine interleukin 6 gene
Shen et al. Human TNF-alpha gene vaccination prevents collagen-induced arthritis in mice
JPH06510419A (en) Interferon-γ-induced monokine-MIG
WO2002081519A9 (en) Ifn-thy fusion protein,dna coding therefore,its preparation and application
Barbero et al. Secretion of mature human interferon alpha 2 into the periplasmic space of Escherichia coli
CN118165125B (en) Fusion protein of recombinant porcine interferon lambda 1, porcine interferon gamma and porcine SA and application thereof
EP0544719A1 (en) Cytokine production
Garret et al. Isolation of a clone which induced expression of the gene encoding the human tumor necrosis factor receptor
Hui et al. Molecular cloning and expression of IL2 cDNA from the Tibet pig
Vishanath DEEMED UNIVERSITY
Li et al. The immunoregulation of mice by somatic transgenic expression of porcine interleukin-6 gene and CpG sequence
AU8333791A (en) Cytokine production