[go: up one dir, main page]

Lieberman et al., 1999 - Google Patents

The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats

Lieberman et al., 1999

View PDF
Document ID
12171171160879354612
Author
Lieberman J
Daluiski A
Stevenson S
JOLLA L
WU L
McALLISTER P
LEE Y
KABO J
FINERMAN G
BERK A
WITTE O
Publication year
Publication venue
JBJS

External Links

Snippet

Background: Recombinant human bone morphogenetic proteins (rhBMPs) can induce bone formation, but the inability to identify an ideal delivery system limits their clinical application. We used ex vivo adenoviral gene transfer to create BMP-2-producing bone-marrow cells …
Continue reading at www.researchgate.net (PDF) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/04—Uses of viruses as vector in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body

Similar Documents

Publication Publication Date Title
Lieberman et al. The effect of regional gene therapy with bone morphogenetic protein-2-producing bone-marrow cells on the repair of segmental femoral defects in rats
Lieberman et al. Regional gene therapy with a BMP‐2‐producing murine stromal cell line induces heterotopic and orthotopic bone formation in rodents
Viggeswarapu et al. Adenoviral delivery of LIM mineralization protein-1 induces new-bone formation in vitro and in vivo
Li et al. Effect of cell‐based VEGF gene therapy on healing of a segmental bone defect
Gulotta et al. Bone marrow–derived mesenchymal stem cells transduced with scleraxis improve rotator cuff healing in a rat model
DE69738640T2 (en) SPATIAL AND TEMPORARY CONTROL OF GENE EXPRESSION BY MEANS OF A HEAT SHOCK PROMOTER IN COMBINATION WITH LOCAL HEAT
US6057300A (en) Methods for treating cancers and restenosis with p21
Sumbilla et al. Comparison of SERCA1 and SERCA2a expressed in COS-1 cells and cardiac myocytes
US20050095227A1 (en) Treating heart failure
JP2004313198A (en) Adenovirus-mediated gene transfer into myocardial and vascular smooth muscle
JPH10501423A (en) Gene transfer-mediated angiogenesis therapy
JPH11507332A (en) Connective tissue growth factor
Okubo et al. In vitro and in vivo studies of a bone morphogenetic protein-2 expressing adenoviral vector
Inesi et al. Cell-specific promoter in adenovirus vector for transgenic expression of SERCA1 ATPase in cardiac myocytes
Kim et al. Overcoming the immune response to permit ex vivo gene therapy for spine fusion with human type 5 adenoviral delivery of the LIM mineralization protein-1 cDNA
Tu et al. Cbfa1/Runx2‐deficiency delays bone wound healing and locally delivered Cbfa1/Runx2 promotes bone repair in animal models
Lee et al. Combined administration of naked DNA vectors encoding VEGF and bFGF enhances tissue perfusion and arteriogenesis in ischemic hindlimb
Nishida et al. Spine update: potential applications of gene therapy to the treatment of spinal disorders
Gao et al. Acceleration of bone-defect repair by using AW MGC loaded with BMP2 and triple point-mutant HIF1α-expressing BMSCs
EA005157B1 (en) Techniques and compositions for treating heart failure and ventricular remodeling by in vivo delivery of angiogenic transgenes
Lou In vivo gene transfer into tendon by recombinant adenovirus
US6660260B1 (en) Bioprosthetic heart valves
Lamsam et al. Gene therapy in sports medicine
Gamradt et al. Tracking expression of virally mediated BMP-2 in gene therapy for bone repair
Song et al. Differential responsiveness to BMP9 between patent and fused suture progenitor cells from craniosynostosis patients