[go: up one dir, main page]

Levine et al., 2017 - Google Patents

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein

Levine et al., 2017

View PDF
Document ID
11355510979847785942
Author
Levine P
De Leon C
Galesic A
Balana A
Marotta N
Lewis Y
Pratt M
Publication year
Publication venue
Bioorganic & medicinal chemistry

External Links

Snippet

The major protein associated with Parkinson's disease (PD) is α-synuclein, as it can form toxic amyloid-aggregates that are a hallmark of many neurodegenerative diseases. α- Synuclein is a substrate for several different posttranslational modifications (PTMs) that have …
Continue reading at pmc.ncbi.nlm.nih.gov (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Similar Documents

Publication Publication Date Title
Levine et al. O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein
Conibear et al. Native chemical ligation in protein synthesis and semi-synthesis
Guimaraes et al. Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions
Hemantha et al. Nonenzymatic polyubiquitination of expressed proteins
Faou et al. Tom34: a cytosolic cochaperone of the Hsp90/Hsp70 protein complex involved in mitochondrial protein import
Hanna et al. Chemical synthesis and semisynthesis of lipidated proteins
Garcia-Dominguez et al. The PHD domain of plant PIAS proteins mediates sumoylation of bromodomain GTE proteins
Dixon et al. Nonenzymatic assembly of branched polyubiquitin chains for structural and biochemical studies
Fraser et al. Generation of a recombinant, membrane-targeted form of the complement regulator CD59: activity in vitro and in vivo
Rut et al. Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Panda et al. Traceless chemical ligation from S-, O-, and N-acyl isopeptides
Chu et al. Ferricyanide-promoted oxidative activation and ligation of protein thioacids in neutral aqueous media
Brown et al. Multiple synthetic routes to the mini-protein omomyc and coiled-coil domain truncations
Tsuda et al. N-sulfanylethylaminooxybutyramide (SEAoxy): A crypto-thioester compatible with Fmoc solid-phase peptide synthesis
Powell et al. Chemical synthesis of microtubule-associated protein tau
Wasmuth et al. Structure–activity studies on the upstream splice junction of a semisynthetic intein
García et al. Cyclodextrin–peptide conjugates for sequence specific DNA binding
US20230265126A1 (en) Ubiquitin high affinity cyclic peptides and methods of use thereof
Richardson et al. Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N→ S acyl transfer
Wu et al. High yield synthesis of cyclic analogues of antibacterial peptides P-113 by Sortase A-mediated ligation and their conformation studies
Debnath et al. Peptide-protein interactions suggest that acetylation of lysines 381 and 382 of p53 is important for positive coactivator 4-p53 interaction
Callahan et al. Same Day Access to Folded Synthetic Proteins
JP2006511193A (en) Semi-synthetic protein-based site-specific probes for active site identification and inhibition, and methods thereof
Singh et al. One-step sortase-mediated chemoenzymatic semisynthesis of deubiquitinase-resistant Ub-peptide conjugates
US20140162285A1 (en) Methods of Modulating Vesicular Trafficking